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The collection consiste of correspondence, memoranda, reports, bulletins, clippings, photographs, awards, and printed material. The files, arranged by genre and topic and reflect her philanthropic and legislative work in the areas of health, specifically cancer, heart disease, and mental health. Her civic and legislative work is covered in detail, as well as her private interests and activities.

Correspondence, manuscripts, lectures, notes, diaries, notebooks, reports, financial records, blueprints, photographs, and printed materials of Y.C. James Yen and the IIRR concerned with the development, sharing, and financing innovative methods of teaching, improving agriculture, health and family planning, and education in impoverished villages. Among the cataloged correspondents are: Pearl Buck, William O. Douglas, Nelson Rockefeller, and DeWitt Clinton.