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Correspondence, manuscripts, notes, drafts of speeches, appointment books, subject files, documents, photographs, memorabilia and printed materials. There are notes from her lectures on Sociology at Adelphi College in 1911-1912; papers from 1912-1932, when Perkins served on the Commission for Safety and on the Industrial Commission of New York State; the main body of the material is from the period of her cabinet office, 1933-1945; and some items from her days on the Civil Service Commission, 1946-1953. Also included are personal and family papers.

The LaGuardia Memorial House Records document the settlement's activities from its earliest years as "The Home Garden" to its current social service programs for the youth of East Harlem. They offer a unique view of the first wave of the settlement movement in America, and document social conditions, demographic change, political activity, philanthropy and social work in East Harlem over a 90 year period. The records include: annual reports, board minutes and correspondence, headworker correspondence, financial records, fundraising information, and photographs.